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. 2011 Dec 20;2(12):1109–1126. doi: 10.18632/oncotarget.380

Figure 5. ATCs are addicted to driver gene signaling.

Figure 5

(A) Western blotting analysis of the activation status of Akt and MAPK pathways in 4-month old control and single mutant mice, ATC-free, progressively older (4, 6, 8 months) double mutants, and histologically confirmed ATCs from 8- to 9-month old double mutants. (B) immunohistochemical detection of activated Akt, S6 ribosomal protein, and ERK1/2 in tumor areas with both well-differentiated and anaplastic components. (C) IC50 values for an Akt inhibitor (MK-2206) and a MEK inhibitor (U0126) in a panel of mouse and human anaplastic (ATC) and follicular (FTC) carcinoma cell lines. On the bottom, a Western blotting showing the effect on the activation of Akt and ERK1/2 of one hour exposure to these inhibitors (MK-2206: 500nM, U0126: 10μM).