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. 2011 Dec 20;2(12):1109–1126. doi: 10.18632/oncotarget.380

Table 1. Top 25 deregulated pathways identified in mouse ATCs, using the Ingenuity Pathways Analysis (IPA) system.

Ingenuity Canonical Pathways P-value Ratio Molecules in pathway
Hepatic Fibrosis / Hepatic Stellate Cell Activation 0.00000 0.347 51/147
Leukocyte Extravasation Signaling 0.00000 0.276 55/199
LPS/IL-1 Mediated Inhibition of RXR Function 0.00000 0.247 54/219
Propanoate Metabolism 0.00000 0.190 23/121
Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 0.00000 0.246 59/240
LXR/RXR Activation 0.00002 0.280 26/93
Valine, Leucine and Isoleucine Degradation 0.00002 0.226 24/106
Metabolism of Xenobiotics by Cytochrome P450 0.00003 0.142 28/197
Atherosclerosis Signaling 0.00003 0.271 29/107
Aryl Hydrocarbon Receptor Signaling 0.00004 0.239 38/157
Urea Cycle and Metabolism of Amino Groups 0.00005 0.179 14/78
Fatty Acid Metabolism 0.00006 0.179 33/184
Arginine and Proline Metabolism 0.00006 0.136 24/177
Pancreatic Adenocarcinoma Signaling 0.00006 0.269 32/119
ILK Signaling 0.00007 0.238 46/193
β-alanine Metabolism 0.00012 0.194 18/93
Glioma Invasiveness Signaling 0.00012 0.333 20/60
Colorectal Cancer Metastasis Signaling 0.00019 0.218 56/257
Inhibition of Angiogenesis by TSP1 0.00019 0.359 14/39
Cell Cycle Control of Chromosomal Replication 0.00021 0.387 12/31
Bladder Cancer Signaling 0.00022 0.283 26/92
HIF1α Signaling 0.00024 0.269 29/108
Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes 0.00025 0.265 27/102
IL-8 Signaling 0.00026 0.223 43/193
TR/RXR Activation 0.00068 0.260 25/96