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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Mol Neurobiol. 2011 Nov 11;44(3):449–464. doi: 10.1007/s12035-011-8214-0

Figure 1. Localization of 5-HT receptors within the prefrontal cortex microcircuit.

Figure 1

Many pyramidal neurons in deep layers co-express 5-HT1A and 5-HT2A receptors. In addition, distinct populations of local inhibitory interneurons that express 5-HT receptors innervate different compartments of the pyramidal tree: 5-HT1A- and 5-HT2A-expressing fast-spiking interneurons are preferentially located in deep layers where they contact pyramidal neurons at the soma and proximal dendrites; slow-spiking interneurons that express 5-HT3A receptors are located in superficial layers where they innervate pyramidal neurons at the distal dendrites. Modified from references 21,178.