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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Mol Neurobiol. 2011 Nov 11;44(3):449–464. doi: 10.1007/s12035-011-8214-0

Figure 3. 5-HT inhibits and activates distinct populations of prefrontal neurons in vivo.

Figure 3

Peri-stimulus histograms depicting the firing rate of pyramidal neurons, fast-spiking and slow-spiking interneurons recorded in the prefrontal cortex of anesthetized rats during electrical stimulation of the dorsal raphe nucleus (time 0), which induces release of 5-HT in the prefrontal cortex. Note that 5-HT1A-mediated inhibitions are shorter in fast-spiking interneurons compared to pyramidal neurons and that 5-HT3A-mediated excitations have a shorter delay and duration than 5-HT2A-mediated excitations. Modified from references 17,48,59,178.