Table 4.
Unadjusted Odds for Fracture Risk per Minor Allele for LRP5 Val667Met, LRP5 Ala1330Val, LRP6 Ile1062Val, and LRP5 Haplotype Allelesa
| SNP, Subgroup | Any Fracture
|
Vertebral Fractures (All Types)
|
||||
|---|---|---|---|---|---|---|
| No.b | OR (95% CI) | P Value | No.b | OR (95% CI) | P Value | |
| LRP5 Val667Met (per Met copy) | ||||||
| Men | 10 975 | 1.09 (0.93–1.27) | .28 | 4782 | 1.14 (0.84–1.57) | .40 |
|
| ||||||
| Women | 20 460 | 1.17 (1.06–1.30) | .003 | 15 706 | 1.29 (1.08–1.54) | .004 |
|
| ||||||
| All | 31 435 | 1.14 (1.05–1.24) | .002 | 20 488 | 1.26 (1.08–1.47) | .004 |
|
| ||||||
| LRP5 Ala1330Val (per Val copy) | ||||||
| Men | 11 035 | 1.07 (0.97–1.17) | .20 | 4786 | 1.11 (0.91–1.36) | .30 |
|
| ||||||
| Women | 20 164 | 1.06 (1.00–1.14) | .06 | 15 310 | 1.12 (1.00–1.26) | .049 |
|
| ||||||
| All | 31 199 | 1.06 (1.01–1.12) | .02 | 20 096 | 1.12 (1.01–1.24) | .03 |
|
| ||||||
| LRP6 Ile1062Val (per Val copy) | ||||||
| Men | 11 102 | 0.98 (0.90–1.07) | .71 | 4849 | 1.23 (1.04–1.46) | .02 |
|
| ||||||
| Women | 20 704 | 1.01 (0.94–1.09) | .69 | 15 838 | 1.01 (0.91–1.12) | .84 |
|
| ||||||
| All | 31 806 | 1.00 (0.95–1.06) | .95 | 20 687 | 1.07 (0.98–1.17) | .15 |
|
| ||||||
| Haplotype (Val667Met-Ala1330Val) | ||||||
| 1 (Val667-Ala1330) | 30 227 | 1 [Reference] | NA | 19 737 | 1 [Reference] | NA |
|
| ||||||
| 2 (Val667-Val1330) | 1.06 (0.95–1.19) | .30 | 1.04 (0.91–1.19) | .59 | ||
|
| ||||||
| 3 (Met667-Val1330) | 1.18 (1.02–1.37) | .02 | 1.28 (1.08–1.55) | .006 | ||
Abbreviations: CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism.
a
Results on single SNPs are based on inverse-variance random-effects analysis of individual-level data. Results on haplotypes are based on linear mixed models.
b
Number of individuals in these analyses.