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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Biol Psychiatry. 2011 Dec 14;71(5):392–402. doi: 10.1016/j.biopsych.2011.09.034

Figure 1. Copy number variant (CNV) discovery, quality control, and annotation workflow.

Figure 1

Tourette syndrome (TS) and control samples were genotyped on Illumina single nucleotide polymorphism (SNP) microarrays. Quality control was performed simultaneously in both cases and controls using SNP, LogR values, and CNV algorithm output. CNVs in remaining samples were annotated to determine rarity. Only CNVs meeting the definition of rare (occurring in <1% of all study samples and Database of Genomic Variants) were carried into further analysis for global burden, de novo burden, overlap with other neurodevelopmental disorders, and pathway analysis.