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. Author manuscript; available in PMC: 2012 Feb 19.
Published in final edited form as: Cell Signal. 2010 Jan 13;22(5):770–782. doi: 10.1016/j.cellsig.2010.01.001

Fig. 12.

Fig. 12

Schematic drawing depicting the role of P-Rex1 in fMLF-stimulted superoxide generation in FPR1-expressing COSphox cells. Solid lines indicate the signaling pathways characterized in neutrophils. Dashed lines represent signaling pathways suggested but not fully investigated in neutrophils. The question mark indicates possible presence of another protein(s) in the reciprocal regulation of Akt and Rac1 in COSphox cells. Several known signaling molecules, e.g., PAK1 for its role in the feed forward mechanism, are not shown due to space limitation. Also not shown are membrane localization of PIP3 and the translocation process of activated Akt, P-Rex1 and PKC. This figure is shown in color in the online version.