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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Nat Neurosci. 2011 Dec 11;15(1):70–80. doi: 10.1038/nn.3000

Figure 5. Effect of the TRPA1 channel blocker (HC 030031) on mIPSCs arriving onto pyramidal neurons and interneurons in the hippocampus.

Figure 5

a. Representative traces for mIPSCs recorded from CA1 pyramidal neurons before and during bath applications of HC 030031 (40 μM) for 8 minutes. The traces and the average cumulative probability plot below shows that HC 030031 produced no effect on mIPSC amplitudes (frequency was also not affected: reported in the text). b. As in a, but for recordings from interneurons. c. Plots the normalized mIPSC amplitude over time for cells where HC 030031 was applied for the duration indicated by the solid black bar in relation to cells where vehicle (0.1% DMSO) was applied. d. Summarizes average mIPSC amplitude and frequency data recorded from interneurons under the indicated conditions. e. HC 030031 did not alter mIPSC amplitudes when astrocytes were previously dialyzed with BAPTA. The parallel control experiments with BAPTA are shown in Supplementary Fig. 13a,b. Vertical lines are s.e.m.