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. Author manuscript; available in PMC: 2012 Feb 20.
Published in final edited form as: J Comp Neurol. 2012 Feb 1;520(2):281–294. doi: 10.1002/cne.22690

Figure 2.

Figure 2

Wildtype and GHSR-null mice maintained on regular chow are equally sensitive to the anorectic actions of acute or chronic leptin treatment. A single injection of leptin (2 μg/g BW, i.p.) reduced body weight A) and overnight food intake (B) similarly in both ad libitum-fed GHSR-null and wildtype littermates. A chronic treatment with twice daily injections of leptin (1 μg/g BW, i.p.) for 3 successive days reduced body weight (C) and average daily food intake during the injection periods (D) similarly in both ad libitum-fed GHSR-null and wildtype littermates. Data represent the mean ± SEM. **P < 0.01.