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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Future Med Chem. 2012 Jan;4(1):33–50. doi: 10.4155/fmc.11.167

Table 3.

Cytotoxicities (IC50, nM) of taxoids and vitamin–linker–taxoid drug conjugates against leukemia and normal human lung fibroblast cells.

Taxane/cojugate L1210FR L1210 WI38
Paclitaxel 121 151 157
SB-T-1214 9.50 9.72 10.7
Biotin–linker–SB-T-1214 (1) 8.80 522 570
SB-T-1214–fluorescein (2) 87.6 107 127
Biotin–linker–SB-T-1214–fluoroscein (Probe C) 81.7 >5000 >5000