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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Stroke. 2011 Dec 8;43(1):286–291. doi: 10.1161/STROKEAHA.111.622225

Figure 3.

Figure 3

MiRNAs in ischemic tolerance. (A) MiRNA screening reveals that the predominant response of miRNAs after preconditioning (P) is upregulation, versus downregulation in ischemia (I) and tolerance (T). (B) MeCP2 (methyl-CpG binding protein) immunostaining shows induction in the cortex 8 h after preconditioning, consistent with decreased expression of MeCP2 miRNA. (C) Infarct is larger in tolerized MeCP2-null mice than in tolerized wildtype (WT) mice. Adapted, with permission, from Lusardi et al, 2010.