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. 2012 Feb 20;3:59. doi: 10.3389/fmicb.2012.00059

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Copyright © 2012 Jackson, Noerenberg and Whitehouse.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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Kaposi’s sarcoma-associated herpesvirus ORF57-mediated intronless viral mRNA nuclear export. ORF57 binds to intronless viral mRNA in the nucleus and interacts directly with the export adapters Aly and UIF. Via the interaction with one or both of these export adapters ORF57 can then recruit the remainder of the hTREX complex, including the proteins UAP56 and the THO complex as well as the export receptor, TAP. ORF57 shuttles this complex through the nucleolus prior to the mRNA being exported into the cytoplasm in a TAP-dependent mechanism. The hTREX components are then recycled back into the nucleus while ORF57 remains bound to the viral mRNA for involvement in further downstream mechanisms.