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. 2012 Feb 20;3:59. doi: 10.3389/fmicb.2012.00059

Figure 5.

Figure 5

Kaposi’s sarcoma-associated herpesvirus ORF57 enhances the translation of intronless viral mRNAs. As well as interacting with the hTREX complex in the nucleus, ORF57 also binds directly to the cellular protein PYM and recruits it to intronless KSHV mRNAs. ORF57 then shuttles through the nucleolus in an mRNP complex with the hTREX components, the intronless viral mRNA, PYM, and possibly other factors before exporting the mRNA. PYM recruits the 48S preinitiation complex to the viral mRNA, enhancing the pioneer round of translation in an ORF57-dependent manner.