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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Cancer Res. 2011 Sep 13;71(21):6888–6898. doi: 10.1158/0008-5472.CAN-11-1011

Figure 5.

Figure 5

PGC1α links mitochondrial and lipogenic functions by inducing SLC25A1 and ACLY. E) PGC1α promotes the expression of ACLY. A) Colons and B) livers from Pgc1α-/- mice have reduced expression of Slc25a1 and Acly compared to Pgc1α+/+ mice. C) Knockdown of PGC1α reduces SLC25A1 and ACLY expression in Colo205 tumors. D) Ectopic expression of PGC1α promotes SLC25A1 and ACLY gene expression in HT29 tumors. RNA was isolated from tissue and RT-PCR performed for SLC25A1 and ACLY as described in materials and methods. N=8-12 ± S.E. *p < 0.05, **p <0.01.