Table 2.

The number of preclinical studies demonstrating features of vascular normalization in the published literature

	Direct antiangiogenics	Indirect antiangiogenics	Genetic models	Total
Structure
Reduced vessel diameter	10a	4b	5c	19
Increased pericyte coverage/proximity	14d	3e	13f	30
Normalized basement membrane	5g	0	1h	6
Function
Improved oxygenation	9i	12j	9k	30
Reduced permeability/IFP	12l	8m	5n	25
Improved delivery of drugs or systemically administered molecules	8o	5p	3q	16

^aYuan et al. 1996; Tong et al. 2004; Dickson et al. 2007b; Taguchi et al. 2008; Falcon et al. 2009; Juan et al. 2009; Kamoun et al. 2009; Chae et al. 2010; Koh et al. 2010; Primo et al. 2010.

^bJain et al. 1998; Izumi et al. 2002; Delmas et al. 2003; Qayum et al. 2009.

^cHamzah et al. 2008; di Tomaso et al. 2009; Nasarre et al. 2009; Van de Veire et al. 2010; Rolny et al. 2011.

^dInai et al. 2004; Tong et al. 2004; Nakahara et al. 2006; Dickson et al. 2007b; Dings et al. 2007; Fischer et al. 2007; Zhou et al. 2008; Falcon et al. 2009; Juan et al. 2009; Kamoun et al. 2009; Ohta et al. 2009; Zhou and Gallo 2009; Chae et al. 2010; Primo et al. 2010.

^eSalnikov et al. 2005; Bhattacharya et al. 2008; Qayum et al. 2009.

^fBenjamin et al. 1999; Dickson et al. 2007a,c; Greenberg et al. 2008; Hamzah et al. 2008; Kashiwagi et al. 2008; Stockmann et al. 2008; di Tomaso et al. 2009; Maione et al. 2009; Mazzone et al. 2009; Nasarre et al. 2009; Rolny et al. 2011; J Liu, S Liao, B Diop-Frimpong, et al., unpubl. data.

^gTong et al. 2004; Winkler et al. 2004; Zhou et al. 2008; Kamoun et al. 2009; Zhou and Gallo 2009.

^hMazzone et al. 2009.

ⁱHansen-Algenstaedt et al. 2000; Lee et al. 2000; Winkler et al. 2004; Dings et al. 2007; Fischer et al. 2007; Eichhorn et al. 2008; Batra et al. 2009; Skuli et al. 2009; McGee et al. 2010.

^jTeicher et al. 1995b; Jain et al. 1998; Bernsen et al. 1999; Cohen-Jonathan et al. 2001; Delmas et al. 2003; Ansiaux et al. 2005, 2006; Pore et al. 2006b; Segers et al. 2006; Cerniglia et al. 2009; Qayum et al. 2009; Cham et al. 2010.

^kAder et al. 2003; Hamzah et al. 2008; Kashiwagi et al. 2008; Stockmann et al. 2008; Maione et al. 2009; Mazzone et al. 2009; Skuli et al. 2009; Tsukada et al. 2009; Rolny et al. 2011.

^lYuan et al. 1996; Lee et al. 2000; Wildiers et al. 2003; Tong et al. 2004; Nakahara et al. 2006; Dickson et al. 2007b; Kurozumi et al. 2007; Taguchi et al. 2008; Zhou et al. 2008; Kamoun et al. 2009; Ohta et al. 2009; Zhou and Gallo 2009.

^mJain et al. 1998; Izumi et al. 2002; Ansiaux et al. 2005; Salnikov et al. 2005; Bhattacharya et al. 2008, 2009; Schnell et al. 2008; Cerniglia et al. 2009.

ⁿDickson et al. 2007c; Kashiwagi et al. 2008; di Tomaso et al. 2009; Mazzone et al. 2009; Rolny et al. 2011.

^oWildiers et al. 2003; Tong et al. 2004; Nakahara et al. 2006; Dickson et al. 2007b; Kurozumi et al. 2007; Zhou et al. 2008; Juan et al. 2009; Zhou and Gallo 2009.

^pTeicher et al. 1995a,b; Segers et al. 2006; Bhattacharya et al. 2008, 2009.

^qDickson et al. 2007a,c; J Liu, S Liao, B Diop-Frimpong, et al., unpubl. data.