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FCG mice are produced by breeding XX gonadal females with XY–Sry gonadal males, producing the four genotypes shown. The figure shows the genetic differences among the four genotypes, in presence/absence of the Y chromosome, number of X chromosomes, and genomic imprint on X genes. Below, FCG mice allow a 2 × 2 comparison to detect the phenotypic effects of sex (Sry present or absent) or sex chromosome (XX vs. XY).
