Table 3.
Factors Associated With Difference in ln(APRI), Entire Cohorta
| Unadjusted |
Adjusted |
|||
| Factor | Fold Change in APRI (95% CI) | P Value | Fold Change in APRI (95% CI) | P Value |
| HIV status | ||||
| Uninfected | 1 | 1 | ||
| Infected | 1.66 (1.57–1.76) | <.001 | 1.39 (1.31–1.49) | <.001 |
| Hepatitis status | ||||
| Uninfected | 1 | 1 | ||
| HBV or HCV infected | 2.04 (1.85–2.25) | <.001 | 1.52 (1.33–1.72) | <.001 |
| HIV-hepatitis interaction | ||||
| No | 1 | |||
| Yes | 1.57 (1.30–1.89) | <.001 | ||
| Age | ||||
| <40 | 1 | 1 | ||
| 40–50 | 1.03 (0.96–1.1) | .4 | 1.05 (0.98–1.11) | .161 |
| ≥50 | 0.96 (0.89–1.03) | .26 | 1.11 (1.03–1.19) | .004 |
Abbreviations: APRI, aspartate aminotransferase-to-platelet ratio index; CI, confidence interval; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus type 1; ln, natural logarithm.
a
Model also adjusts for heavy alcohol use, body mass index, white race, and year of Multicenter AIDS Cohort Study visit.