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. 2012 Jan 19;18(2):171–197. doi: 10.1093/humupd/dmr047

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© The Author 2012. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Imprinting in the germline. Erasure, establishment and maintenance of methylation imprints at imprinting control regions during germ cell and embryonic development. Imprinting control regions (IC1) and IC2 are shown as examples. Grey indicates modification and white indicates no modification at the corresponding alleles. Parental chromosomes are marked according to their sex in blue (male) or red (female). The reading in the developing embryo is indicated by arrows. Figure from Reik and Walter (2001).