Figure 3.

Algorithm based on pharmacodynamic concept.

Notes: *Diabetes mellitus, left main stenosis, diffuse atherosclerotic disease, chronic renal failure and acute coronary syndromes. **Avoid in patients aged >75 years or weighing <60 kg; contraindicated in patients with history of TIA or stroke. ***High-dose clopidogrel option; 600 mg loading and 150 mg daily, guided by PFA.

Abbreviations: IPA, inhibition of platelet aggregation; PFA, platelet function assay; PRU, P2Y12 reaction units;TIA, transient ischemic attack.