Table 2.
Selected reagents used for siRNA delivery.
| Reagent | Route of administration (model used) | Reference |
|---|---|---|
| Naked siRNAs | Intranasal (mouse) | [59] |
| Intravaginal (mouse) | [16,42] | |
|
| ||
| Cholesterol-siRNA | Systemic (mouse) | [36] |
| Intravaginal (mouse) | [17] | |
|
| ||
| Positively charged protein/Peptide-antibody-siRNA | Systemic (mouse) | [47,48] |
|
| ||
| Aptamer-siRNA | Systemic (mouse) | [66,67] |
|
| ||
| SNALPs | Systemic (cynomolgus monkey) | [37] |
| Systemic (mouse) | [84] | |
|
| ||
| Nanoparticles | Intravaginal (mouse) | [35] |
| Systemic (mouse) | [85] | |
SNALP stable nucleic acid-lipid particles