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Effect of HO-1 overexpression on the amelioration of radiation-induced skin injury. Rats were irradiated to the buttock skin with a single dose of 45 Gy followed by an injection of PBS, 5 × 109 genomic copies of Ad-EGFP or Ad-HO1-EGFP (8 animals per group). Skin injury in these groups was measured using a semi-quantitative score of 1 (no damage) to 5 (severe damage). * P < 0.05, compared with PBS-injected control group.
