Table 2.
Correlation between combined p53 mutation and p14ARF, DAPK, and/or ASC/TMS1 methylation with pathologic biology in cholangiocarcinoma
| combined p53 mutation and p14ARF, DAPK, and/or ASC/TMS1 methylation | ||||
|---|---|---|---|---|
| Pathologic character | cases | positive | positive ratio (%) | P-value |
| Pathologic type | ||||
| Tubular carcinoma | 18 | 5 | 27.8 | |
| Papillary carcinoma | 9 | 1 | 11.1 | |
| Mucoid carcinoma | 4 | 4 | 100.0 | |
| Non-differentiated | 5 | 4 | 80.0 | < 0.05 |
| carcinoma | ||||
| Differentiation | ||||
| Well -Moderate | 25 | 6 | 24.0 | |
| Poor | 11 | 8 | 72.7 | < 0.05 |
| Invasion | ||||
| T1 | 16 | 2 | 12.5 | |
| T2 | 10 | 4 | 40.0 | |
| T3 | 10 | 8 | 80.0 | < 0.05 |
| Lymph node metastasis | ||||
| N0 | 3 | 0 | 0 | |
| N1 | 33 | 14 | 42.4 | > 0.05 |