Table 1.
Results of cytotoxic activity on the SW-480 human colon cancer cell line, antiradical DPPH assay, ferric reducing antioxidant power, total flavonoid content, and total phenolic content of methanol extracts and compounds 1-3 and 8 from the pulp and seeds of the fruits of S. samarangense
| Compounds/Methanol extract | Cytotoxic activity a, IC50 | DPPHa, IC50 | FRAP c | TFC d | TPC e |
|---|---|---|---|---|---|
| 1 | 10 | 205 ± 1.2 b | 196 ± 0.0 | NT | NT |
| 2 | 35 | 141 ± 2.3 | 191 ± 0.1 | NT | NT |
| 3 | 35 | 124 ± 3.4 | 173 ± 0.0 | NT | NT |
| 8 | 60 | 199 ± 0.8 | 196 ± 0.5 | NT | NT |
| Pulp methanol extract | 60 | 72.9 ± 0.0 | 14.8 ± 0.2 | 294 ± 0.0 | 460 ± 0.0 |
| Seeds methanol extract | NS | 78.4 ± 0.0 | 31.3 ± 0.2 | 19.9 ± 0.0 | 1278 ± 0.1 |
| EGCG | 50 | ||||
| Gallic acid | 25.0 ± 0.1 |
a
Cytotoxic and antiradical DPPH activity are expressed as IC50 in μM for pure compound and μg/ml for extracts.
b
Mean ± S.D. (n = 3);
c
Expressed as μM trolox equivalents/500 μmol for pure compound and μmol trolox/g fresh weight for extracts;
d
Total flavonoid content (TFC) expressed as mg quercetin/100 g fresh weight;
e
Total phenolic content (TPC) expressed as mg gallic acid/100 g fresh weight; NS: Not completely soluble. NT: Not tested.