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. 2012 Feb 20;7(2):e31275. doi: 10.1371/journal.pone.0031275

Table 3. Patient Subgroups Based on Modeled Recovery Trajectories.

Subgroup Model Parameters Goodness-of-Fit
No. I 95% CI β 95% CI c 95% CI SSE AICc w
ExpC 4 −10.6 −7.1 −14.1 −0.017 −0.003 −0.031 −2.6 −0.7 −4.6 11.29 17.21 0.75
6 −31.1 −14.9 −47.3 −0.023 −0.001 −0.045 −3.8 −0.6 −8.3 93.06 36.47 0.97
13 −51.2 −24.4 −77.9 −0.042 −0.015 −0.069 −3.5 −0.7 −6.2 57.77 35.01 0.90
14 −16.4 −13.4 −19.4 −0.027 −0.017 −0.038 −2.6 −1.5 −3.7 7.20 12.71 0.97
17 −93.8 −75.0 −112.5 −0.041 −0.025 −0.058 −6.3 −2.2 −10.3 130.00 41.65 0.83
18 −10.7 −1.5 −17.8 −0.017 −0.013 −0.047 −3.0 −2.0 −3.9 7.98 11.32 0.93
Mean * −34.7 −8.8 −67.2 −0.025 −0.017 −0.035 −3.2 −2.3 −4.4
Exp 1 −7.2 −5.6 −8.8 −0.013 −0.004 −0.021 2.61 2.55 0.91
2 −10.5 −9.0 −12.0 −0.027 −0.021 −0.032 1.17 −7.57 0.97
3 −2.6 −1.5 −3.7 −0.007 −0.001 −0.012 2.90 −2.38 0.65
5 −2.8 −1.6 −3.9 −0.047 −0.001 −0.095 0.91 7.99 0.97
7 −11.1 −8.4 −13.8 −0.061 −0.029 −0.094 2.18 0.76 0.99
8 −1.7 −1.2 −2.3 −0.018 −0.004 −0.033 0.27 −25.50 0.93
10 −2.5 −2.0 −3.0 −0.026 −0.015 −0.037 0.16 −25.30 1.00
12 −5.4 −3.3 −7.4 −0.024 −0.007 −0.040 5.01 3.08 0.69
19 −5.7 −4.4 −7.1 −0.030 −0.015 −0.045 1.11 1.53 1.00
20 −7.4 −5.7 −9.1 −0.043 −0.018 −0.069 2.79 3.23 1.00
21 −6.9 −4.2 −9.7 −0.072 −0.006 −0.138 4.29 1.53 0.57
22 −4.2 −2.9 −5.6 −0.015 −0.007 −0.022 2.27 −4.84 0.89
23 −3.6 −2.4 −4.7 −0.059 −0.003 −0.115 1.00 −7.03 1.00
27 −3.2 −1.5 −4.9 −0.022 −0.004 −0.048 2.00 −0.08 1.00
26 −14.4 −9.5 −19.2 −0.012 −0.005 −0.019 33.68 22.14 0.74
28 −13.1 −10.5 −15.5 −0.055 −0.028 −0.071 3.08 −1.78 0.80
29 −27.6 −19.5 −35.6 −0.020 −0.009 −0.031 98.82 32.91 0.80
Mean −6.8 −3.7 −13.2 −0.029 −0.020 −0.046
Lin 9 −3.7 −3.2 −4.2 0.016 0.013 0.019 5.23 29.90 0.92
11 1.0 1.5 0.5 0.003 0.005 0.001 3.85 25.89 0.84
15 −0.2 1.0 −1.4 −0.001 0.006 −0.008 28.20 41.82 0.80
16 −0.6 1.0 −2.1 0.007 0.016 −0.002 50.90 50.65 0.69
24 −2.6 −1.5 −3.7 0.011 0.018 0.004 23.30 40.10 0.98
25 1.1 1.5 0.7 0.004 0.007 0.001 3.73 24.52 0.47
Mean −0.9 0.4 −2.2 0.006 0.010 0.002

Patient subgroups based on whether they showed exponential trajectories converging to an impairment z-score<−2.5 (subgroup ExpC), exponential trajectories converging to an impairment z-score of 0±2.5 (subgroup Exp) or linear trajectories (subgroup Lin). Parameter values are standardized to scores of healthy volunteers; lower values indicate a higher degree of impairment. Model parameters are: I = Intercept (initial deficit), β = exponent (rate of recovery), c = constant (plateau reached at the end of the observation period). Abbreviations: AICc = Akaike Information Criterion with bias correction for small sample sizes; No. = patient number, SSE = model sum of squared errors; w = normalized Akaike weights, i.e. conditional probability of chosen model given the data and the candidate set of models.

*Weighted mean and corresponding 95% CI, i.e. average of individual parameters multiplied with corresponding Akaike weight.