Table 3. Patient Subgroups Based on Modeled Recovery Trajectories.

Subgroup	Model Parameters										Goodness-of-Fit
	No.	I	95% CI		β	95% CI		c	95% CI		SSE	AICc	w
ExpC	4	−10.6	−7.1	−14.1	−0.017	−0.003	−0.031	−2.6	−0.7	−4.6	11.29	17.21	0.75
	6	−31.1	−14.9	−47.3	−0.023	−0.001	−0.045	−3.8	−0.6	−8.3	93.06	36.47	0.97
	13	−51.2	−24.4	−77.9	−0.042	−0.015	−0.069	−3.5	−0.7	−6.2	57.77	35.01	0.90
	14	−16.4	−13.4	−19.4	−0.027	−0.017	−0.038	−2.6	−1.5	−3.7	7.20	12.71	0.97
	17	−93.8	−75.0	−112.5	−0.041	−0.025	−0.058	−6.3	−2.2	−10.3	130.00	41.65	0.83
	18	−10.7	−1.5	−17.8	−0.017	−0.013	−0.047	−3.0	−2.0	−3.9	7.98	11.32	0.93
	Mean *	−34.7	−8.8	−67.2	−0.025	−0.017	−0.035	−3.2	−2.3	−4.4
Exp	1	−7.2	−5.6	−8.8	−0.013	−0.004	−0.021				2.61	2.55	0.91
	2	−10.5	−9.0	−12.0	−0.027	−0.021	−0.032				1.17	−7.57	0.97
	3	−2.6	−1.5	−3.7	−0.007	−0.001	−0.012				2.90	−2.38	0.65
	5	−2.8	−1.6	−3.9	−0.047	−0.001	−0.095				0.91	7.99	0.97
	7	−11.1	−8.4	−13.8	−0.061	−0.029	−0.094				2.18	0.76	0.99
	8	−1.7	−1.2	−2.3	−0.018	−0.004	−0.033				0.27	−25.50	0.93
	10	−2.5	−2.0	−3.0	−0.026	−0.015	−0.037				0.16	−25.30	1.00
	12	−5.4	−3.3	−7.4	−0.024	−0.007	−0.040				5.01	3.08	0.69
	19	−5.7	−4.4	−7.1	−0.030	−0.015	−0.045				1.11	1.53	1.00
	20	−7.4	−5.7	−9.1	−0.043	−0.018	−0.069				2.79	3.23	1.00
	21	−6.9	−4.2	−9.7	−0.072	−0.006	−0.138				4.29	1.53	0.57
	22	−4.2	−2.9	−5.6	−0.015	−0.007	−0.022				2.27	−4.84	0.89
	23	−3.6	−2.4	−4.7	−0.059	−0.003	−0.115				1.00	−7.03	1.00
	27	−3.2	−1.5	−4.9	−0.022	−0.004	−0.048				2.00	−0.08	1.00
	26	−14.4	−9.5	−19.2	−0.012	−0.005	−0.019				33.68	22.14	0.74
	28	−13.1	−10.5	−15.5	−0.055	−0.028	−0.071				3.08	−1.78	0.80
	29	−27.6	−19.5	−35.6	−0.020	−0.009	−0.031				98.82	32.91	0.80
	Mean	−6.8	−3.7	−13.2	−0.029	−0.020	−0.046
Lin	9	−3.7	−3.2	−4.2	0.016	0.013	0.019				5.23	29.90	0.92
	11	1.0	1.5	0.5	0.003	0.005	0.001				3.85	25.89	0.84
	15	−0.2	1.0	−1.4	−0.001	0.006	−0.008				28.20	41.82	0.80
	16	−0.6	1.0	−2.1	0.007	0.016	−0.002				50.90	50.65	0.69
	24	−2.6	−1.5	−3.7	0.011	0.018	0.004				23.30	40.10	0.98
	25	1.1	1.5	0.7	0.004	0.007	0.001				3.73	24.52	0.47
	Mean	−0.9	0.4	−2.2	0.006	0.010	0.002

Patient subgroups based on whether they showed exponential trajectories converging to an impairment z-score<−2.5 (subgroup ExpC), exponential trajectories converging to an impairment z-score of 0±2.5 (subgroup Exp) or linear trajectories (subgroup Lin). Parameter values are standardized to scores of healthy volunteers; lower values indicate a higher degree of impairment. Model parameters are: I = Intercept (initial deficit), β = exponent (rate of recovery), c = constant (plateau reached at the end of the observation period). Abbreviations: AICc = Akaike Information Criterion with bias correction for small sample sizes; No. = patient number, SSE = model sum of squared errors; w = normalized Akaike weights, i.e. conditional probability of chosen model given the data and the candidate set of models.

*Weighted mean and corresponding 95% CI, i.e. average of individual parameters multiplied with corresponding Akaike weight.