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. 2012 Feb 20;7(2):e31573. doi: 10.1371/journal.pone.0031573

Figure 6. Effect of VPA on the mRNA expression of haemostatic genes.

Figure 6

HUVECs (from four individuals) were stimulated with 4 mM VPA for 24 h and mRNA from treated and untreated cells were analyzed using the Human Gene 1.0 ST microarray. Haemostasis genes (a total of 138 genes) were identified using the Amigo database and plotted in the order of increasing log2 fold change. Probe sets with a log2 ratio above +1 or below −1 and a significantly changed expression (p<0.05, FDR adjusted p-value) were classified as regulated. The dot representing t-PA is highlighted (log Fold Change 2.18). The other regulated haemostasis genes are: Tissue factor pathway inhibitor 2 (TFPI2) (log Fold Change 1.18), signal peptide CUB domain EGF-like 1 (SCUBE1) (log Fold Change 1.67), coagulation factor II (thrombin) receptor-like 2 (F2RL2) (log Fold Change 1.75), P-selectin (log Fold Change −1.21) and fermitin family homolog 3 (drosophila) (FERMT3) (log Fold Change −1.20).