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. 2012 Feb 20;7(2):e32015. doi: 10.1371/journal.pone.0032015

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Cao et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Compared with WT littermates (A and C), strong immunostaining for the microglial marker Iba-1 was observed in the hippocampus of Bmi-1^−/− mice (B and D). Activated microglia with large soma and thick processes (arrowheads) were present at Bmi-1^−/− mice (D).