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miR-33a inhibition improves insulin secretion and cholesterol levels in apoE knockout (apoEKO) islets. GSIS (20 mmol/L; n = 3) (A) and total cholesterol (n = 3) (B) in islets isolated from control wild-type or apoEKO mice infected with GFP or miR-33a-Inh adenovirus (Ad). Quantified values are normalized to protein (total cholesterol) or DNA (insulin secretion). *P < 0.05, **P < 0.01.
