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. 2012 Feb 13;61(3):674–682. doi: 10.2337/db11-0510

FIG. 5.

FIG. 5.

Inhibition of insulin receptor impairs glucose tolerance in euglycemic transplant mice. S981, a competitive antagonist of the insulin receptor, was administered immediately prior to glucose tolerance test. S961 resulted in impairment of glucose tolerance in both normal controls (n = 4) (A) and BAT transplant recipients euglycemic at 3 months (n = 5) (B). A: P < 0.05, when 60- and 120-min time points are compared with and without S961. B: P < 0.05, when 120-min time point is compared with and without S961.