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. 2012 Feb 13;61(3):586–596. doi: 10.2337/db11-1091

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© 2012 by the American Diabetes Association.

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FIG. 6. — Rosiglitazone treatment reduces oxidative stress through iNOS modulation while it improves insulin sensitivity in the liver. A: Representative spectra of lipid free radical production in SHHF rats before and after a 10-day regimen of rosiglitazone (Rosi) treatment. B: Rosiglitazone treatment significantly reduced the level of lipid radical formation (n = 5, *P < 0.05). C: Treatment almost completely blunted iNOS protein levels in the SHHF rat liver. D: Improved OGTT response in SHHF rats after 10 days of thiazolidinedione treatment. E: Improved insulin signaling (p85 attachment and IRS-1 phosphorylation) in SHHF liver upon rosiglitazone treatment. n = 4, representative blots and immunoprecipitations of several independent experiments. a.u., arbitrary unit; IP, immunoprecipitation; IB, immunoblotting. (A high-quality color representation of this figure is available in the online issue.)