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. Author manuscript; available in PMC: 2013 Jan 20.
Published in final edited form as: Circ Res. 2011 Dec 15;110(2):265–274. doi: 10.1161/CIRCRESAHA.111.253260

Figure 3. Overexpression of β2AR mutant lacking PKA phosphorylation sites increases adverse pressure overload-induced ventricular remodeling.

Figure 3

Figure 3

(A) Representative serial M-mode echocardiography in conscious NTG, WT TG, PKA- TG or GRK2- TG mice measured before and 5 weeks after TAC. (B) Summary data of Left Ventricular Internal Dimension-Diastole (LVIDd), Left Ventricular Internal Dimension-Systole (LVIDs), Left Ventricular Posterior Wall Dimensions-diastole (LVPWd), Left Ventricular Posterior Wall Dimensions-Systole (LVPWDs), Ejection Fraction (EF), and Fractional Shorting (FS). Data are presented as means ± SE (n = 8–12 in each group) and data was analyzed with a two-way repeated measures analysis of variance (ANOVA). Bonferroni correction was applied for multiple comparisons. *p<0.05 PKA- TG v.s. other four groups. (C) Survival curves. Kaplan-Meier Survival Analysis, *P<0.05 PKA- TG v.s. other three groups (GRK2- TG, WT TG, and NTG) (n=28, 25, 24 and 25 for PKA- TG, WT TG, GRK2- TG, and NTG, respectively).