Table 2.
Cohort, 20% Subcohort, and Case-Cohort Analyses of the Association Between Highly Active Antiretroviral Therapy and Incident AIDS or Death Among 950 Men and Women Infected With HIV Type 1, Multicenter AIDS Cohort Study and Women’s Interagency HIV Study, 1996–2007
| Analysis and Model | Hazard Ratio | 95% Confidence Interval | Standard Errora |
| Cohort | |||
| Unadjusted | 1.02 | 0.72, 1.43 | 0.176 |
| Adjustedb | 0.96 | 0.68, 1.36 | 0.178 |
| Weightedb | 0.41 | 0.26, 0.65 | 0.231 |
| Subcohort | |||
| Unadjusted | 1.27 | 0.57, 2.86 | 0.412 |
| Adjusted | 1.37 | 0.60, 3.17 | 0.426 |
| Weighted | 0.53 | 0.23, 1.24 | 0.436 |
| Case-cohort | |||
| Unadjusted | 0.97 | 0.61, 1.54 | 0.238 |
| Adjusted | 1.09 | 0.69, 1.73 | 0.235 |
| Weighted | 0.47 | 0.26, 0.83 | 0.293 |
Abbreviations: AIDS, acquired immunodeficiency syndrome; HIV, human immunodeficiency virus.
a
Standard error for log hazard ratio; robust standard error for case-cohort and weighted models.
b
Adjusted and weighted models both controlled for time-varying prior CD4 cell count and HIV-1 RNA level, specified as restricted cubic splines.