Table II.
Positiona | FcγRIIab | FcγRIII | FcγRI | FcεRI |
---|---|---|---|---|
Human FcRs | ||||
90 | W | W | W | W |
113 | W | W | W | W |
117 | P | A | I | D |
119 | V | H | V | V |
120 | K | K | N | K |
128 | K | K | K | F |
129 | S | G | A | A |
132 | F | Y | F | Y |
134 | H/R (R) | H | H | Y |
135 | L (S) | H | W | F |
160 | Y | S | K | Q |
Eu Indexc | IgG1 | IgG2 | IgG3 | IgG4 |
Human IgG subclasses | ||||
234 | L | V | L | F |
235 | L | A | L | L |
236 | G | – | G | G |
237 | G | G | G | G |
239 | S | S | S | S |
265 | D | D | D | D |
266 | V | V | V | V |
267 | S | S | S | S |
297 | N | N | N | N |
327 | A | G | A | G |
328 | L | L | L | L |
329 | P | P | P | P |
Position in amino acid sequence corresponding to the numbering scheme for crystal structures described in this article and reported previously (17, 24).
Residues in parentheses occur in FcγRIIb. The same numbering scheme has been used for FcγRIIb.
Numbering for IgG is the Eu Index (62).
–, deletion in the sequence.