. 2011 Nov 17;86(3):393–403. doi: 10.1007/s00204-011-0768-0

Table 1.

Comparison of our model simulations with literature human data and published PBTK model results

Compound	C_ss (steady-state concentration) for 1 mg kg⁻¹ day⁻¹ dose (μM)	Present study
2,4- Dichlorophenoxyacetic acid	9.05–90.05	44.47
Oxytetracycline dehydrate	0.36	2.31
Triclosan	2–10	2.18
Bisphenol A	<0.13	0.31
Parathion	0.17	0.24

	Plasma elimination half-life	Present study
Thioridazine	26 (h)	87 (days)
Warfarin	(R-isomer) 46 ± 7(h) (S-isomer) 36 ± 13 (h)	40 (h)
DDT	5–8 (years)	2 (years)
PCBs	10–15 (years)	7 (years)
PFOS	2.4–21.7 (years)	2.5 (years)

	C_max (maximum concentration) (μM)	Present study
Chlorpyrifos	~0.01^a	0.013
Propranolol	0.15^b 0.23^c	0.12 0.24

C_max (maximum concentration) (μM)

Present study

Chlorpyrifos

~0.01^a

0.013

Propranolol

0.15^b

0.23^c

0.12

0.24

^afor 1 mg kg⁻¹ day⁻¹ dose; ^b for 10 mg day⁻¹ dose; ^c for 20 mg day⁻¹ dose