Table 2.
Patients and tissue details of control patients
| Case | Age | Sex | Hallmark of clinical diagnosis | Brain autopsy findings | PM interval (h) | Muscles | Muscle findings |
|---|---|---|---|---|---|---|---|
| C1 | 79 | M | Endocarditis, pancreas carcinoma. | Without pathological changes | ~30 | Cervical paraspinal | Neurogenic atrophy, type II hypotrophy + |
| Deltoid | Neurogenic atrophy, type II hypotrophy +++ | ||||||
| C2 | 77 | F | Lung embolism | Microinfarct of cornu ammonis | 34 | Cervical paraspinal | Type II atrophy/hypotrophy + |
| Deltoid | Type II atrophy/hypotrophy ++ | ||||||
| C3 | 55 | F | Rectal carcinoma | Without pathological changes | ~48 | Cervical paraspinal | Type II atrophy ++ |
| Deltoid | Type II atrophy ++ | ||||||
| C4 | 67 | F | Hypertension | Hemorrhage of basal ganglia, old infarct | ~24 | Lumbar paraspinal | COX-def. fibers ++; type II atrophy + |
| Deltoid | Type II atrophy ++ | ||||||
| C5 | 82 | F | Endocarditis, apoplexy (left cerebral artery) | Small cerebral infarcts | ~24 | Cervical paraspinal | Lymphocytic infiltrates +++, type II atrophy+ |
| Lumbar paraspinal | Lymphocytic infiltrates +; type II atrophy++ | ||||||
| Deltoid | Lymphocytic infiltrates +++; type II atrophy++ | ||||||
| C6 | 54 | F | Acute myeloic leucemia; allogenic stem cell therapy; graft versus host reaction | Without pathological changes | 66 | Cervical paraspinal | Neurogenic ++; type II atrophy+++ |
| Lumbar paraspinal | type II atrophy+++ | ||||||
| Deltoid | Neurogenic atrophy +++; type II atrophy | ||||||
| C7 | 73 | M | Prostate carcinoma. Urosepsis, transitory ischemic attack with acute respiratory distress syndrome | Two small microinfarcts in the midbrain | ~24 | Cervical paraspinal | Type II hypotrophy +++ |
| Lumbar paraspinal | Neurogenic atrophy +++; type II hypotrophy ++ | ||||||
| Deltoid | Neurogenic atrophy ++; type II hypotrophy ++ | ||||||
| C8 | 47 | M | Sepsis, spinal canal stenosis, type II-diabetes | Without pathological changes | 24 | Cervical paraspinal | Unspecific changes |
| Lumbar paraspinal | Unspecific changes | ||||||
| Deltoid | Unspecific changes | ||||||
| C9 | 77 | M | Large cell anaplastic B-cell lymphoma, dilative cardiomyopathy | Remnants of hypoxia | 24 | Cervical paraspinal | type II atrophy+++; neurogenic atrophy + |
| Deltoid | type II atrophy++; neurogenic atrophy + | ||||||
| C10 | 54 | M | Pneumonia, sepsis, multi-organ failure | Septic embolism, severe hypoxia | 18 | Cervical paraspinal | Neurogenic atrophy +; type II fiber hypotrophy |
| Lumbar paraspinal | Neurogenic atrophy +; type II fiber hypotrophy | ||||||
| Deltoid | Type II fiber hypotrophy |
Changes within muscle biopsies were rated semiquantitatively as + mild, ++ moderate or +++ severe