Table 1.

Identification of RA regulated genes by microarray

Gene Symbol	Gene Name	Fold Change (KO vs Control)	p-value	Predicted response to RA	Reference for RA regulation
Adm	Adrenomedullin	1.4	0.026	INCREASE	Minamino et al., 1995
Col2a1	Collagen II, subunit a1	-1.47	0.006	DECREASE	Jimenez et al., 2001
Clu	Clusterin	-1.4	0.019	DECREASE	Orlandi et al., 2005
Dlx3	Distalless-like homeobox 3	-1.6	0.005	DECREASE	Acquafreda et al., 2010
Itga2b	Integrin alpha 2, subunit b	-1.31	0.017	DECREASE	Liu et al., 2000
Itgb3	Integrin beta 3	-1.29	0.014	DECREASE	Csomos et al., 2010
Mia1	Melanoma inhibitory activity	-1.45	0.039	DECREASE	Dietz et al., 1996
Myt1	Myelin transcription factor 1	1.58	0.044	INCREASE	Franco et al., 1999
Otor	Otoraplin	-1.28	0.009	DECREASE	Roberts et al., 2000
Cp	Ceruloplasmin	1.37	0.017	INCREASE	Tice et al., 2002
Bhmt	Betaine-homocysteine methyltransferase	-1.27	0.002	DECREASE	Xu et al., 2010
S100a8	S100 calcium binding protein A8	-1.29	0.025	DECREASE	Liu et al., 2000
Hoxc9	Homeobox C9	-1.3	0.001	DECREASE	Mao et al., 2011
Aplnr	Apelin receptor	-1.27	0.2	DECREASE	Zhong et al., 2005
Msc	Musculin	-1.34	0.037	DECREASE	Hishikawa et al., 2005
Ncam1	Neural cell adhesion molecule 1	1.26	0.016	INCREASE	De Laurenzi et al., 2000
Fgf4	Fibroblast growth factor 4	-1.26	0.048	DECREASE	Maerz et al., 1998
Pak1	p21 protein activated kinase 1	1.3	0.049	INCREASE	Csomos et al., 2010
Vwf	Von Willebrand factor	1.32	0.0235	INCREASE	Hatzopoulos et al., 1998

Microarray analysis of Mes^t-KO E12.5 periotic tissue (OV and surrounding POM) reveals changes in genes regulated by retinoic acid (RA). Gene expression changes are consistent with previously published data implicating either activation or repression by treatment with retinoic acid in cell culture or other model organisms, as indicated. Fold change versus control and p-values from microarray analysis are presented for these selected genes. For full microarray expression data, see Supplemental Table 1