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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Cancer Lett. 2011 Oct 10;316(1):11–22. doi: 10.1016/j.canlet.2011.10.006

Fig. 1.

Fig. 1

CTS selectively inhibits DHT-mediated AR transactivation, but not the ER, PR, and GR activity. A: Structure similarity of DHT and CTS. Left: DHT structure Right: CTS structure, similar to DHT, contains three cyclohexane rings (designated as rings A, B, and C in the left panel) and one furan ring (the D ring) composed of seventeen carbon atoms. B & C: Inhibition of CTS on the androgen-induced AR transcriptional activity in HEK 293 cells. D-F: No effects of CTS on the transcriptional activities of estrogen-induced ERα, Dex-induced GR, and progesterone-induced PR in HEK 293 cells. G: Inhibition of CTS on the DHT-induced AR transcriptional activity of a gain-function mutant AR (T877A) in prostate cancer LNCaP cells. H: Inhibition of CTS on the DHT-induced AR transcriptional activity in CWR22Rv1 cells. MMTV-Luc or ERE-Luc activities were determined. Data represent mean ± SD from three independent experiments. I & J: Inhibition of CTS on the R1881 induced AR transcriptional activity in LNCaP and CWR22Rv1 cells.