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. 2011 Sep 30;38(3):119–125. doi: 10.5653/cerm.2011.38.3.119

Figure 2.

Figure 2

Proposed roles of uterine dendritic cells (DCs) in the regulation of angiogenesis and T cell action at the maternal-fetal interface. Monocytes are recruited to the uterus and differentiate into mature tolerogenic cells such as uDCs, under the influence of colony-stimulating factor (CSF-1), GM-CSF, and interleukin (IL)-4. Uterine DCs produce soluble FMS-like tyrosine kinase 1 (sFLT1) and transforming growth factor (TGF)-β1. sFLT1, a soluble form of VEGFR1, modulates the actions of vascular endothelial growth factor (VEGF), and TGF-β1 influences endothelial cell viability and suppresses cytotoxic CD8+ T cell function and development of regulatory T (Treg) cells ( Modified from Pollard JW. J Clin Invest 2008;118: 3832-5 [12]).