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Possible mechanisms of the origin, expansion, migration, and function of Treg cells during pregnancy. APC, antigen presenting cells; TGF-β, transforming growth factor-β; IL, interleukin; LIF, leukemia inhibitor factor; HO-1, heme-oxygenase-1 (Modified from Leber A, et al. Am J Reprod Immunol 2010;63:445-59 [28]).
