Table 3.
Mean-Weighted Effect Sizes for Cognitive Domains for Cannabis Using and Nonusing Schizophrenia Patients Defined by Lifetime Use Vs Current or Recent Use Criteria
Test | Number of Studies | SCZ + CANN | SCZ − CANN | Cohen’s d | 95 % CI | z | P | Q-test, P | Bias Test |
Global cognition | 10 | 223 | 349 | 0.35 | 0.09 to 0.61 | 2.63 | .009 | 17.13* | 0.34 |
Lifetime | 6 | 121 | 138 | 0.55 | 0.30 to 0.80 | 4.29 | <.001 | 3.95 | |
Current/recent | 4 | 102 | 211 | 0.03 | −0.30 to 0.37 | 0.20 | .84 | 4.59 | |
Attention | 3 | 68 | 67 | 0.26 | −0.08 to 0.61 | 1.51 | .13 | 0.50 | 0.26 |
Processing speed | 8 | 192 | 322 | 0.40 | 0.11 to 0.69 | 2.75 | .006 | 14.62* | 0.39 |
Lifetime | 5 | 103 | 124 | 0.65 | 0.38 to 0.92 | 4.70 | <.001 | 1.72 | |
Current/recent | 3 | 89 | 198 | 0.09 | −0.34 to 0.52 | 0.42 | .67 | 4.87 | |
Visual memory | 3 | 87 | 91 | 0.45 | 0.13 to 0.77 | 2.76 | .006 | 2.24 | 0.98 |
Verbal memory | 4 | 101 | 184 | 0.0 | −0.51 to 0.51 | 0 | .99 | 10.1* | 0.75 |
Lifetime | 3 | 78 | 67 | 0.18 | −0.32 to 0.77 | 0.63 | .53 | 4.78 | |
Planning | 4 | 81 | 122 | 0.47 | 0.05 to 0.90 | 2.20 | .03 | 5.92 | 0.39 |
Lifetime | 3 | 59 | 73 | 0.67 | 0.31 to 1.03 | 3.65 | <.001 | 1.20 | |
Working memory | 4 | 94 | 213 | 0.13 | −0.40 to 0.55 | 0.48 | .63 | 11.58* | 0.61 |
Lifetime | 2 | 49 | 47 | 0.64 | 0.22 to 1.05 | 3.00 | .003 | 0.16 | |
Current/recent | 2 | 45 | 166 | −0.28 | −0.61 to 0.06 | 1.62 | .10 | 0.12 |
Note: Bold values indicate comparisons that were significantly different between the SCZ + CANN and the SCZ − CANN groups.
*P < .05.