Table 3. Clinical and genetic features of patients with multiple neoplasia including a neuroblastic tumour.
First tumour | Second tumour | Genetic results |
---|---|---|
Unilateral retinoblastoma, 16 months | Adrenal ganglioneuroblastoma, 9 years | ALK, RB1 wt |
Unilateral nephroblastoma, 9 months | Adrenal neuroblastoma, 9 months | No 11p15 LOI, ALK, CDKN1C wt |
Neuroblastoma, 3 years | Rhabdoid tumour, 22 years | ALK wt, SMARCB1 wt |
Abdominal NB, 5 years | Desmoid tumour, 27 years | ALK wt |
Melanoma, 22 years | Adrenal neuroblastoma, 30 years | ALK, CDK4, CDKN2A wt |
Neuroblastoma, 9 months | Nerve sheath tumour, 28 years | ALK wt |
Neuroblastoma, 8 years | Liposarcoma, 28 years | ALK wt |
Abdominal neuroblastoma, 3 years | Medulloblastoma, 3 years | ALK wt |
Abbreviations: RB, retinoblastoma; wt, wild type; LOI, loss of imprinting.