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. 2012 Feb 7;18:362–371.

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Copyright © 2012 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Histopathology. A: The corneal specimen from the proband of the NTUH-18 family showed irregular thickness of the epithelium, vacuolization in the basal epithelium, and focal subepithelial fibrosis interposed between the irregular epithelium with a “sawtooth-like” configuration (PAS staining, 200×). B: Focal disruption of Bowman’s membrane (arrows) was replaced by subepithelial fibrotic tissue (star) (H&E staining, 400×). C: The specimen from the proband of the NTUH-11 family showed several eosinophilic deposits interspersed within the entire corneal stromal layer (H&E staining, 200×). D: These deposits showed green birefringence under a polarized microscope (Congo red staining, 200×).