Skip to main content
. 2012 Feb;15(1):59–70. doi: 10.1089/rej.2011.1226

Table 2.

Summary of the Effects of Moderate Age and Calorie Restriction on Pre- and Postischemic Protein Kinase Signaling by Akt, GSK3β, p70S6K, and p38-MAPK

 
Cardiac expression level
Preischemic phosphorylation
Postischemic phosphorylation
Protein kinase Age (MA vs. YA) CR (MA-CR vs. MA) Age (MA vs. YA) CR (MA-CR vs. MA) Age (MA vs. YA) CR (MA-CR vs. MA)
Akt (prosurvival) ↑ ↑ ↑↑↑
p70S6K (prosurvival) ↓ ↓ ↑ ↑ ↑↑↑ ↓ ↓ ↑↑↑
p38-MAPK (prosurvival/death?) ↑↑↑
GSK3β (prodeath) ↑↑↑ ↓ ↓ ↑↑↑

Relative changes in Akt, GSK3β, p70S6K, and p38-MAPK levels and phosphorylation in middle-aged (MA) versus young (Y) hearts, and with CR in MA hearts: (↑) increased; (↓) decreased; (−) unchanged. (↑ or ↓) 10%−40% change; (↑ ↑ or ↓ ↓) 41%−70% change; (↑↑↑ or ↓↓↓) >70+% change. Responses are derived from data in Figs. 4 and 5.

CR, Calorie reduction; YA, young adult; MAPK, mitogen-activation protein kinse.