Table 6.

Optic neuritis, comparison of clinical features according to the patient's AQP4-Ab serostatus.

	Seropositive	Seronegative	p-level
Annualized ON relapse rate†
All patients with a history of ON	0.38 (0.04-2.25; N = 83)	0.36 (0.08-3; N = 21)	n.s.§
Patients meeting Wingerchuk's 2006 criteria	0.37 (0.04-2.25; N = 80)	0.25 (0.08-3; N = 19)	n.s.§
Bilateral ON ever
All patients with a history of ON	25/92 (27.2%)	15/29 (51.7%)	p < 0.023‡
Patients meeting Wingerchuk's 2006 criteria	23/87 (26.4%)	14/27 (51.9%)	p < 0.019‡
Bilateral ON at first ON attack*
All patients with a history of ON	12/85 (14.1%)	11/28 (39.3%)	p < 0.007‡
Patients meeting Wingerchuk's 2006 criteria	12/81 (14.8%)	10/26 (38.5%)	p < 0.023‡
ON attacks with VA ≤ 0.1
All patients with a history of ON	83/123 (67.5%)	13/35 (37.1%)	p < 0.002‡
Patients meeting Wingerchuk's 2006 Criteria	74/112 (66.1%)	12/33 (36.4%)	p < 0.005‡
Attacks with complete recovery
All patients with a history of ON	68/205 (33.2%)	15/51 (29.4%)	n.s.‡
Patients meeting Wingerchuk's 2006 Criteria	64/190 (33.7%)	13/42 (31%)	n.s.‡

^†Only patients with a disease duration > = 12 months were considered. *Irrespective of whether at disease onset or not. ^‡Fisher's exact test (2-tailed). ^§Mann Whitney U test. ON = optic neuritis; N = number of patients (not all data were available from all patients); n.s. = not significant; VA = visual acuity.