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. 2012 Jan 18;104(4):311–325. doi: 10.1093/jnci/djr545

Figure 3.

Figure 3

Concordance of classifiers for breast cancer molecular subtyping. A) Colored bars illustrate the molecular subtypes as computed by each of the six classifiers applied to the compendium of 5715 breast tumors. SCMGENE, the three-gene subtype classification model, was used as the reference, that is, the patients (tumors) were unambiguously ordered using the maximum posterior probabilities estimated by SCMGENE. B) The corresponding risk predicted by the prognostic gene signatures. C) Clinical parameters: estrogen receptor (ER) and progesterone receptor (PGR) status defined by immunohistochemistry (IHC); HER2 status defined by IHC or fluorescent in situ hybridization (FISH); histological grade assessed separately in each dataset; and age at diagnosis (> 50 y) and tumor size (> 2 cm) are binary variables. GGI = prognostic gene signature (16); MAMMAPRINT = prognostic gene signature (14); ONCOTYPE = prognostic gene signature (15); PAM50 = single sample predictor (3); SCMOD1 = subtype classification model 1 (1); SCMOD2 = subtype classification model 2 (8); SSP2003 = single sample predictor (6); SSP2006 = single sample predictor (2).