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. 2012 Feb 21;7(2):e30960. doi: 10.1371/journal.pone.0030960

Table 5. Pathogenesis of infection with LP VN/1203/K and LP VN/1203/E in chickens.

Virus Day pi No. Ag+ (Ave Score of Positive Tissues)A Virus Isolation: No Pos/TotalB
Heart Brain SkinC OtherD Spleen Lung Brain ThromE TotalF
K 1 0/6 0/6 0/6 0/6 1/6 0/6 0/6 0/6 1/6
2 0/6 0/6 0/6 0/6 0/6 1/6 0/6 0/6 1/6
3 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6 0/6*
4 0/6 1/6 (1) 1/6 (1) 1/6 (1) 2/6 1/6 2/6 0/6 2/6
5 0/6 0/6 0/6 0/6 0/6 0/6 2/6 0/6 2/6
E 1 0/6 0/6 0/6 0/6 1/6 1/6 0/6 0/6 2/6
2 0/6 0/6 0/6 0/6 0/6 1/6 0/6 0/6 1/6
3 1/6 (1) 0/6 1/6 (1) 1/6 (1) 5/6 4/6 5/6 0/6 6/6*
4 1/6 (1) 1/6 (1) 1/6 (1) 1/6 (1) 1/6 1/6 1/6 1/6 3/6
5 2/6 (1) 1/6 (1) 2/6 (1) 2/6 (1) 1/6 3/6 1/6 0/6 3/6
UC 1+5 0/6 0/6 0/6 0/6 0/12 0/12 0/12 0/12 0/12
A

Number of samples positive for virus antigen as measured by immunohistochemistry. Scoring system: 1 = Antigen sparse, 2 = Antigen common, 3 = Antigen abundant.

B

Virus isolation was performed by inoculation of 3 embryonated chicken eggs per tissue sample.

C

Includes dermis of feathered skin, feather pulp and comb; for other tissues see the result section.

D

Other tissues are liver, kidney tubules, spleen, lung interstitium, connective tissues, lymphoid follicles, and salivary glands.

E

Thrombocytes.

F

Number of birds with one or more positive tissues.

*Significantly different from each other (P<0.05, two-tailed Fisher's exact test).