Table 1. Phenotype of Brg1Wap-Cre mutant mice.
Phenotype | |||||
Gender | Category | Genotype 1 | #Litters * | Mammary | Ovary/Uterus |
Male | control | +/floxed, Tg | N/A | none | N/A |
Male | control2 | null/floxed, Tg | N/A | none | N/A |
Male | control2 | null/floxed, Tg | N/A | none | N/A |
Male | control2 | floxed/floxed, Tg | N/A | none | N/A |
Female | control | floxed/floxed | 4 | none | none3 |
Female | control | +/null, Tg | 4 | none | none |
Female | control | +/+, Tg | 4 | none | none |
Female | control | +/+, Tg | 4 | none | none |
Female | control | +/floxed, Tg | 2 | none | none |
Female | control | +/null | 4 | none | none |
Female | control | null/floxed | 3 | none | none |
Female | control | null/floxed | 3 | none | none |
Female | control | null/floxed | 3 | none | none |
Female | control | +/floxed, Tg | 3 | none | none |
Female | control | null/floxed | 2 | none | none |
Female | control | floxed/floxed | 2 | none | none |
Female | mutant | null/floxed, Tg | 4 | none | uterine tumor |
Female | mutant | null/floxed, Tg | 4 | none | ovarian cyst |
Female | mutant | null/floxed, Tg | 4 | none | ovarian cyst, uterine tumor |
Female | mutant | null/floxed, Tg | 2 | none | uterine tumor |
Female | mutant | null/floxed, Tg | 3 | none | ovarian cyst |
Female | mutant | null/floxed, Tg | 3 | none | none |
Female | mutant | floxed/floxed, Tg | 4 | none | none |
Female | mutant | floxed/floxed, Tg | 3 | none | ovarian cyst |
Female | mutant | floxed/floxed, Tg | 3 | none | ovarian cyst, uterine tumor |
Female | mutant | floxed/floxed, Tg | 3 | none | ovarian cyst |
Female | mutant | floxed/floxed, Tg | 3 | none | ovarian cyst |
Female | mutant | null/floxed, Tg | 3 | none | ovarian cyst |
Female | mutant | floxed/floxed, Tg | 2 | none | ovarian cyst |
Female | mutant | floxed/floxed, Tg | 3 | none | ovarian cyst |
Female | mutant | floxed/floxed, Tg | 3 | none | ovarian cyst |
Female | mutant | null/floxed, Tg | 3 | none | ovarian cyst |
Female | mutant | floxed/floxed, Tg | 3 | none | ovarian cyst |
Female | mutant | null/floxed, Tg | 2 | none | ovarian cyst |
Female | mutant | null/floxed, Tg | 2 | none | ovarian cyst |
Female | mutant | null/floxed, Tg | 2 | none | ovarian cyst |
Female | mutant | floxed/floxed, Tg | 2 | none | none |
*First pregnancy was at 2–3 months of age, and all mice were analyzed at 15–19 months of age.
Tg was hemizygous in each case (Wap-Cre+/0).
Mutant genotypically but considered a control because Cre transgene expression is induced by pregnancy, which does not occur in males.
Did not score for ovarian or uterine phenotype.