Table 2. Phenotype of Brg1Wap-Cre mutant mice on a Brm-deficient background.
Phenotype | |||||
Gender | Category | Genotype 1 | #Litters * | Mammary | Ovary/Uterus |
Female | control | floxed/floxed, Brm−/− | 3 | none | none |
Female | control | floxed/floxed, Brm−/ | 3 | none | none |
Female | control | floxed/floxed, Brm−/− | 3 | none | none |
Female | control | floxed/floxed, Brm−/− | 2 | none | none |
Female | control | floxed/floxed, Brm+/− | 2 | none | none |
Female | control | floxed/floxed, Brm−/− | 3 | none | none |
Female | double mutant | floxed/floxed, Tg, Brm−/− | 3 | none | none |
Female | double mutant | floxed/floxed, Tg, Brm−/− | 3 | none | ovarian cyst |
Female | double mutant | floxed/floxed, Tg, Brm−/− | 2 | none | ovarian cyst |
Female | double mutant | floxed/floxed, Tg, Brm−/− | 2 | none | none |
Female | double mutant | floxed/floxed, Tg, Brm−/− | 3 | none | ovarian cyst |
Female | double mutant | floxed/floxed, Tg, Brm−/− | 2 | none | ovarian cyst |
Female | double mutant | floxed/floxed, Tg, Brm−/− | 3 | none | none |
Female | double mutant | floxed/floxed, Tg, Brm−/− | 2 | none | ovarian cyst |
*First pregnancy was at 2–3 months of age, no lactation defects were observed, and all mice were analyzed at 15–19 months of age.
Tg was hemizygous in each case (Wap-Cre+/0).