Table 6. Mutation in uvrY gene down regulates inflammatory cytokine expression.

Genotype	Fold change in mRNA levels of SV-HUC-1 ureter cells treated with
	Purified LPS (10 ng)			Whole bacterial cells
	TNFα	IL6	IL8	TNFα	IL6	IL8
CFT073 WT	3.7±0.3↑	5.5±0.4↑	2.2±0.3↑	8.7±0.6↑	17.4±0.9↑	12.08±0.5↑
uvrY	1.0±0.6↓*	2.0±0.1↓*	1.6±0.4↓*	2.1±0.3↑**	3.6±0.1↑**	1.4±0.4↓**
uvrY/p-uvrY	2.9±0.3↑	4.9±0.3↑	2.1±0.2↑	8.2±0.9↑	17.8±0.5↑	12.1±0.7↑
csrA	1.8±0.2↑*	3.6±0.2↑*	1.5±0.1↑	3.6±0.6↑*	6.1±0.4↑*	4.3±0.4↑**
csrA/p-csrA	1.1±0.4↑	1.8±0.7↑	1.0±0.2↑	2.0±0.2↑	3.2±0.3↑	1.5±0.7↑

The values are mean ± SD of three independent experiments with triplicate samples.

The downward arrow indicates down regulation compared to the WT.

(*, p≤0.05; **, p≤0.01 compared to WT).