Table 3. Distribution of the 822 bp mtDNA deletion in major mtDNA haplogroups among subjects pooled from cases and controls.
| MtDNA haplogroups | Del (n = 206) (%) | Non-Del (n = 740) (%) | p value (X 2) | Adjusted p valuea | OR (95% CI)a |
| A (n = 74) | 15 (7.28) | 59 (7.97) | 0.883 | 0.967 | 0.987 (0.543–1.795) |
| B (n = 185) | 35 (16.99) | 150 (20.27) | 0.322 | 0.302 | 0.805 (0.534–1.215) |
| M8 (n = 82) | 15 (7.28) | 67 (9.05) | 0.486 | 0.295 | 0.729 (0.404–1.317) |
| G (n = 49) | 11 (5.34) | 38 (5.14) | 0.860 | 0.861 | 1.065 (0.528–2.148) |
| F (n = 159) | 41 (19.90) | 118 (15.95) | 0.206 | 0.090 | 1.416 (0.941–2.096) |
| D (n = 214) | 65 (31.55) | 149 (20.14) | <0.001 | <0.001 | 1.906 (1.359–2.738) |
| M7 (n = 87) | 16 (7.77) | 71 (9.59) | 0.496 | 0.189 | 0.677 (0.380–1.210) |
| Others (n = 96) | 8 (3.88) | 88 (11.89) | NA | NA | NA |
χ 2-Test or Fisher's exact test.
For multiple comparisons, p value was set <0.05/2×(n−1) (n = 8).
a
, ORs (95% CIs) and p value determined by multivariate logistic regression analysis, adjusted for age, gender and pack-years of smoking.