Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
When the PPAR is activated, it recruits RXR, forming an intermediary heterodimer, which has the LBDs and DBDs domains in extended and open conformation. Following to DNA binding, the PPAR/RXR heterodimers suffer additional conformational changes, becoming more condensed and less solvent-exposed.
